• Hsin-Hung Chen, Ching-Chu Chen, Ming-Chia Hsieh, Chun-Wei Ho, Sheng-Pang Hsu, Hei-Tung Yip, and Chia-Hung Kao.
• Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung, Taiwan.
• Curr Med Res Opin. 2020 Jun 1; 36 (6): 1063-1067.

AbstractBackground: To investigate the association between Graves' disease (GD) and polycystic ovary syndrome (PCOS) and its comorbidities.Methods: Logistic regression was performed to determine the association between the two conditions. Cumulative incidence curves were obtained using the Kaplan-Meier method and log-rank test. Hazard ratios were determined using the Cox proportional hazards regression model.Results: We included 5399 patients with GD as the study group and 10,798 patients without GD as the control group. The cumulative incidence curve of PCOS in patients with GD was significantly higher than that in patients without GD (p = .02). The adjusted hazard ratio for PCOS in patients with GD compared with patients without GD was 1.47 (95%CI = 1.09-1.98). The adjusted odds ratio of hyperlipidemia in patients with GD and PCOS was 2.18 (95%CI = 1.14-4.17) higher than that in patients with GD only.Conclusion: Our study demonstrated that women with GD could be at risk of developing PCOS; additionally, a higher incidence of comorbidities, including hyperlipidemia, was noted in women with GD and PCOS.

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