• Neth J Med · Aug 2019

    Case Reports

    Large-vessel vasculitis associated with PEGylated granulocyte-colony stimulating factor.

    • K Yukawa, S Mokuda, Y Yoshida, S Hirata, and E Sugiyama.
    • Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
    • Neth J Med. 2019 Aug 1; 77 (6): 224-226.

    AbstractA 71-year-old female with advanced endometrial cancer was treated with pegfilgrastim. She developed a fever within seven days, and contrast-enhanced computed tomography scans repeated within three days revealed rapidly progressive thickening of the aortic wall. When clinicians administer PEGylated granulocyte-colony stimulating factor (G-CSF) to cancer patients, drug-associated vasculitis should be suspected. This report discusses the manifestation of G-CSF-associated large-vessel vasculitis (LVV).

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