• Neth J Med · Feb 2020

    Case Reports

    Viral encephalitis associated with rituximab maintenance therapy: two cases and a review of literature.

    • D P Noij, T den Heijer, and H C T van Zaanen.
    • Department of Internal Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.
    • Neth J Med. 2020 Feb 1; 78 (1): 37-40.

    AbstractRituximab is increasingly used in the treatment of CD20-positive B-cell-mediated disease. Prolonged use may cause B-cell dysfunction, dose-dependent T-cell dysfunction, and hypogammaglobulinaemia and result in severe non-neutropenic infections. We present two cases of viral encephalitis in patients treated with rituximab maintenance therapy: one patient presented with deafness; the other patient with paroxysmal light flashes, apraxia, and weakness.

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