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Case Reports
Viral encephalitis associated with rituximab maintenance therapy: two cases and a review of literature.
- D P Noij, T den Heijer, and H C T van Zaanen.
- Department of Internal Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.
- Neth J Med. 2020 Feb 1; 78 (1): 37-40.
AbstractRituximab is increasingly used in the treatment of CD20-positive B-cell-mediated disease. Prolonged use may cause B-cell dysfunction, dose-dependent T-cell dysfunction, and hypogammaglobulinaemia and result in severe non-neutropenic infections. We present two cases of viral encephalitis in patients treated with rituximab maintenance therapy: one patient presented with deafness; the other patient with paroxysmal light flashes, apraxia, and weakness.
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