• Am. J. Med. Sci. · Sep 2020

    Review Case Reports

    IgA Nephropathy Concomitant With Karyomegalic Interstitial Nephritis.

    • Ziliang Wang, Xiaona Ni, Shuangshuang Zhu, and Shuling Yue.
    • Department of Nephrology, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, China. Electronic address: lwlh2009wch76@126.com.
    • Am. J. Med. Sci. 2020 Sep 1; 360 (3): 287-292.

    AbstractImmunoglobulin A (IgA) nephropathy is one of the most common glomerulonephritis characterized by the deposition of IgA in glomerular mesangium. Karyomegalic interstitial nephritis (KIN) is a rare interstitial nephritis with potential hereditary factors. IgA nephropathy concomitant with KIN has not yet been reported. Herein, we describe the clinical course, ultrasonic images and gastrointestinal endoscopy findings of a 28-year-old-male patient with IgA nephropathy with KIN. The pathologic examination of the renal biopsy specimen demonstrated mild mesangial proliferative IgA nephropathy with KIN. Molecular genetic testing detected an abnormality in FAN1 gene. The heterozygous mutation was present on chromosome 15q13.3. However, IgA nephropathy with KIN is a rare disorder, and its pathogenesis is yet to be clarified.Copyright © 2020 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

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