• J. Cardiothorac. Vasc. Anesth. · Dec 2013

    Randomized Controlled Trial

    Outcomes and Biochemical Parameters Following Cardiac Surgery: Effects of Transfusion of Residual Blood Using Centrifugation and Multiple-Pass Hemoconcentration.

    • Erick McNair, William McKay, Abdul Mohamed Qureshi, Mark Rosin, Jon Gamble, Greg Dalshaug, Taras Mycyk, and Kailash Prasad.
    • Department of Surgery; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan and Royal University Hospital, Saskatoon, SK, Canada. Electronic address: erick.mcnair@usask.ca.
    • J. Cardiothorac. Vasc. Anesth.. 2013 Dec 1;27(6):1174-80.

    ObjectivesTo determine whether or not there was a significant difference between the methods of centrifugation (CF) and multiple-pass hemoconcentration (MPH) of the residual cardiopulmonary-bypass volume in relation to biochemical measurements and patient outcomes.DesignProspective, randomized, and controlled.SettingConducted at a western Canadian tertiary care hospital.ParticipantsConsisted of 61 consecutive male and female patients from ages 40 to 80 who were scheduled for cardiac surgery with cardiopulmonary bypass.InterventionsEither the centrifugation or multiple-pass hemoconcentration method was used to process the residual blood from the cardiopulmonary bypass circuit.ResultsThe 12-hour postoperative levels of serum hemoglobin were not significantly different in the centrifugation group as compared to the multiple-pass hemoconcentration group. However, the serum levels of total protein and albumin were significantly higher in the multiple-pass hemoconcentration group as compared to the centrifugation group. Additionally, after 12-hours postoperatively, the serum fibrinogen and platelet counts were significantly higher in the multiple-pass hemoconcentration group as compared to those of the centrifugation group. The allogeneic product transfusion index and the chest-tube blood drainage indices were lower in the multiple-pass hemoconcentration group as compared to the centrifugation group.ConclusionAlthough the CF method provided a product in a shorter turnaround time, with consistent clearance of heparin, the MPH method trended towards enhanced biochemical and clinical patient outcomes over the 12-hour postoperative period.Copyright © 2013 Elsevier Inc. All rights reserved.

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