• Venkatesh Thiruganasambandamoorthy, Andrew D McRae, Brian H Rowe, Sivilotti Marco L A MLA Queen's University, Kingston, Ontario, Canada (M.L.S.)., Muhammad Mukarram, Marie-Joe Nemnom, Ronald A Booth, Lisa A Calder, Ian G Stiell, George A Wells, Wei Cheng, and Monica Taljaard.
• University of Ottawa and The Ottawa Hospital, Ottawa, Ontario, Canada (V.T., L.A.C., I.G.S.).
• Ann. Intern. Med. 2020 May 19; 172 (10): 648-655.

BackgroundStudies have reported that natriuretic peptides provide prognostic information for emergency department (ED) syncope.ObjectiveTo evaluate whether adding N-terminal pro-B-type natriuretic peptide (NT-proBNP) to the Canadian Syncope Risk Score (CSRS) improves prediction of 30-day serious adverse events (SAEs).DesignProspective cohort study.Setting6 EDs in 2 Canadian provinces.Participants1452 adult ED patients with syncope.InterventionSerum NT-proBNP was measured locally at 1 site and batch processed at a central laboratory from other sites. The concentrations were not available to treating physicians or for adjudication of outcomes.MeasurementsAn adjudicated composite outcome of 30-day SAEs, including death and cardiac (arrhythmic and nonarrhythmic) and noncardiac events.ResultsOf 1452 patients enrolled, 152 (10.5% [95% CI, 9.0% to 12.1%]) had 30-day SAEs, 57 (3.9%) of which were identified after the index ED disposition. Serum NT-proBNP concentrations were significantly higher among patients with SAEs than those without them (median, 626.5 ng/L vs. 81 ng/L; P < 0.001). Adding NT-proBNP values to the CSRS did not significantly improve prognostication (c-statistic, 0.89 and 0.90; P = 0.12 for difference), regardless of SAE subgroup or whether the SAE was identified after the index ED visit. The net reclassification index shows that NT-proBNP would have correctly reclassified 3% of patients with SAEs at the expense of incorrectly reclassifying 2% of patients without SAEs.LimitationsOur study was powered to detect a 3% difference in the area under the curve. The heterogeneity of outcomes and robust baseline discrimination by the CSRS will make improvements challenging.ConclusionAlthough serum NT-proBNP concentrations were generally much higher among ED patients with syncope who had a 30-day SAE, this blood test added little new information to the CSRS. Routine use of NT-proBNP for ED syncope prognostication is not recommended.Primary Funding SourcePhysicians' Services Incorporated Foundation, Canadian Institutes of Health Research, and The Ottawa Hospital Academic Medical Organization.

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