• Soo Min Ok, Jin Hwa Kim, Ji Su Kim, Eun Gyo Jeong, Yang Mi Park, Hye Mi Jeon, Jun Young Heo, Yong Woo Ahn, Sun Nyoung Yu, Hae Ryoun Park, Kyung Hee Kim, Soon Cheol Ahn, and Sung Hee Jeong.
• Department of Oral Medicine, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Korea.
• Yonsei Med. J. 2020 Apr 1; 61 (4): 331-340.

PurposeOsteoarthritis (OA) of the temporomandibular joint (TMJ) elicits cartilage and subchondral bone defects. Growth hormone (GH) promotes chondrocyte growth. The aim of this study was to evaluate the efficacy of intra-articular injections of GH to treat TMJ-OA.Materials And MethodsMonosodium iodoacetate (MIA) was used to induce OA in the TMJs of rats. After confirming the induction of OA, recombinant human GH was injected into the articular cavities of rats. Concentrations of GH and IGF-1 were measured in the blood and synovial fluid, and OA grades of cartilage and subchondral bone degradation were recorded by histological examination and micro-computed tomography.ResultsMIA-induced OA in the rat TMJ upregulated insulin-like growth factor-1 (IGF-1) rather than GH levels. GH and IGF-1 concentrations were increased after local injection of GH, compared with controls. Locally injected GH lowered osteoarthritic scores in the cartilage and subchondral bone of the TMJ.ConclusionIntra-articular injection of GH improved OA scores in rat TMJs in both cartilage and subchondral bone of the condyles without affecting condylar bone growth. These results suggest that intra-articular injection of human GH could be a suitable treatment option for TMJ-OA patients in the future.© Copyright: Yonsei University College of Medicine 2020.

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