• Ciro Oliveira Queiroz, Francisco Pitanga, Paulo Andrade Lotufo, Maria Del Carmen Bisi Molina, Estela Maria Leão de Aquino, and Maria Conceição Chagas Almeida.
• MSc. Assistant Professor, Department of Physical Education, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil. Postgraduate Student, Postgraduate Program in Biotechnology in Health and Investigative Medicine, Centro de Pesquisa Gonçalo Muniz (CPqGM), Fundação Oswaldo Cruz (FIOCRUZ), Salvador (BA), Brazil.
• Sao Paulo Med J. 2020 Jan 1; 138 (1): 192619-26.

BackgroundStudies have shown that physical activity levels can be inversely associated with high-sensitivity C-reactive protein (hs-CRP) levels. However, the amount of physical activity required to maintain normal hs-CRP levels is still a matter for speculation.ObjectiveTo identify the amount of physical activity necessary to discriminate the hs-CRP levels in adults.Design And SettingCross-sectional study at six teaching and research institutions.MethodsThe study sample comprised 10,231 adults aged 35 to 74 years who were participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Receiver operating characteristic (ROC) curves were constructed to compare the amount of physical activity in two domains (leisure time and commuting) with hs-CRP levels. The sensitivity and specificity were calculated to identify the best cutoff for physical activity level that would be needed to maintain normal levels of hs-CRP (< 3 mg/l).ResultsThe area under the ROC curve was only statistically significant for discriminating normal levels of hs-CRP according to the amount of physical activity when the two study domains were added together. The accumulated physical activity level of 200 minutes/week was the best cutoff for discriminating normal levels of hs-CRP in adults of both sex.ConclusionsPhysical activity in the leisure-time and commuting domains together, of duration 200 minutes/week, was associated with normal hs-CRP values.

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