• Internal medicine journal · Nov 2019

    Multicenter Study

    Association between ribociclib and changes in creatinine in patients with hormone receptor positive metastatic breast cancer.

    • Brooke E Wilson, Kelly Mok, Belinda E Kiely, Rebecca Nguyen, and Eugene Moylan.
    • Department of Medical Oncology, Liverpool Hospital, Sydney, New South Wales, Australia.
    • Intern Med J. 2019 Nov 1; 49 (11): 143814421438-1442.

    AbstractCombination ribociclib and aromatase inhibitors are currently the preferred treatment in Australia for newly diagnosed hormone receptor positive metastatic breast cancer in the absence of visceral crisis. In our case series of 32 patients, 28% experienced grade 1 elevations in creatinine, a toxicity that was under-recognised in large phase III studies. Creatinine rise appears to be due to a reversible inhibition of renal efflux transporters rather than an acute kidney injury in the majority of cases.© 2019 Royal Australasian College of Physicians.

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