• Internal medicine journal · Apr 2020

    Case Reports

    Successful kidney transplantation in a patient with stable multiple myeloma.

    • Christina Lai, Tracey Ying, P Joy Ho, Kate Wyburn, Martin Gallagher, and Steve Chadban.
    • Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
    • Intern Med J. 2020 Apr 1; 50 (4): 492-494.

    AbstractRenal failure is a common feature of multiple myeloma affecting 20-55% of patients at the initial presentation and is being associated with a significant increase in morbidity and mortality. Renal transplantation for patients with multiple myeloma is rarely considered given the incurable nature of the disease, the risk of post-transplant disease progression and perceived high risk of infections. Here we report a 57-year-old man with end-stage renal failure attributed to presumed IgA nephropathy, with pre-existing stable multiple myeloma, who received a kidney transplant from a two haplotype-matched sibling. Transplantation has been successful and with excellent kidney function and stable multiple myeloma 6 years post-transplant. This case highlights the potential benefits of renal transplantation in highly selected patients with multiple myeloma.© 2020 Royal Australasian College of Physicians.

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