• J Chin Med Assoc · Jul 2019

    Overexpression of Smac is associated with the development of primary Sjogren's syndrome.

    • Yuanyuan Kang and Ying Zhang.
    • J Chin Med Assoc. 2019 Jul 1; 82 (7): 541545541-545.

    BackgroundPrimary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by keratoconjunctivitis sicca, xerostomia, and extraglandular abnormalities. The precise etiology remains unclear. Previous studies have revealed that the apoptosis played an important role in the pSS. Herein, we investigated the expression and effect of second mitochondria-derived activator of caspase (Smac) in patients with pSS and associated the expression with clinicopathological parameters.MethodsSmac expression was checked in labial salivary glands of surgical specimens from cases of pSS using immunohistochemistry, reverse transcription-quantitative PCR, and Western blot. The results of immunohistochemistry were analyzed for clinicopathological parameters. In addition, the content of Smac in cytoplasm and mitochondria were examined.ResultsThe mRNA of Smac, the content of Smac in cytoplasm, the Smac protein in the pSS patients increased significantly compared with the healthy controls (p < 0.05). The content of Smac in mitochondria decreased significantly compared with the healthy controls (p < 0.05). The integral optical density of Smac protein levels were positively correlated with IgG (r = 0.7435, p < 0.05) and erythrocyte sedimentation rate (ESR) (r = 0.7925, p < 0.05).ConclusionSmac plays an important role in the development of pSS.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…