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- Sheng-Fan Wang, Kuan-Hsuan Chen, Szu-Yu Wang, Aliaksandr A Yarmishyn, Wei-Yi Lai, Yi-Ying Lin, Mong-Lien Wang, Shih-Jie Chou, Yi-Ping Yang, and Yuh-Lih Chang.
- Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
- J Chin Med Assoc. 2020 Aug 1; 83 (8): 712-718.
AbstractRecently, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was quickly identified as the causal pathogen leading to the outbreak of SARS-like illness all over the world. As the SARS-CoV-2 infection pandemic proceeds, many efforts are being dedicated to the development of diverse treatment strategies. Increasing evidence showed potential therapeutic agents directly acting against SARS-CoV-2 virus, such as interferon, RNA-dependent RNA polymerase inhibitors, protease inhibitors, viral entry blockers, neuraminidase inhibitor, vaccine, antibody agent targeting the SARS-CoV-2 RNA genome, natural killer cells, and nucleocytoplasmic trafficking inhibitor. To date, several direct anti-SARS-CoV-2 agents have demonstrated promising in vitro and clinical efficacy. This article reviews the current and future development of direct acting agents against SARS-CoV-2.
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