• Diego Cipriano Chagas, Maria da Conceição Barros-Oliveira, Pedro Vitor Lopes-Costa, Renato de Oliveira Pereira, Mariella de Almeida Melo, Danylo Rafhael Costa-Silva, Carine Soares Borges, Jackeline Lopes Viana, Alesse Ribeiro Dos Santos, Gil Facina, and Benedito Borges da Silva.
• Programa de Pos Graduacao em Ciencias da Saude, Universidade Federal do Piaui, Teresina, PI, BR.
• Clinics (Sao Paulo). 2020 Jan 1; 75: e1643.

ObjectivesAromatase inhibitors are the first-choice drugs for the treatment of hormone sensitive breast cancer. However, in addition to the scarcity of studies, there are controversies about their effects on vaginal epithelial cell proliferation in rats, especially those in persistent estrus.MethodsTo investigate vaginal epithelial cell proliferation by Ki-67 antigen expression, persistent estrus was induced in 42 randomly selected rats. These rats were randomly divided into 2 groups: group I (control, n=21), which received 0.1 mL of propylene glycol (vehicle) daily, and group II (experimental, n=21), which received 0.5 mg/kg or 0.125 mg/day of anastrozole diluted with 0.1 mL of propylene glycol.ResultsLight microscopy showed a higher concentration of cells with brown Ki-67 stained nuclei in the control compared to the experimental group. The mean percentage of Ki-67 stained nuclei per 500 cells in the vaginal epithelium was 68.64±2.64 and 30.46±2.00 [mean±standard error of the mean (SEM)] in the control and experimental groups, respectively (p<0.003).ConclusionThis study showed that anastrozole, at the dose and treatment duration selected, significantly decreased cell proliferation in the vaginal mucosa of the rats in persistent estrus.

18 keywords...

hide…