• Rev Med Interne · Oct 2019

    Case Reports

    [Anogenital granulomatosis as extradigestive Crohn disease: Efficiency of adalimumab therapy].

    • J Castagna, F Aubin, and F Pelletier.
    • Service de dermatologie et allergologie, CHU Besançon, 3, boulevard Fleming, 25000 Besançon, France. Electronic address: julie.castagna@sfr.fr.
    • Rev Med Interne. 2019 Oct 1; 40 (10): 677-679.

    IntroductionAnogenital granulomatosis is a rare disease which is actually considered as a metastatic lesion of Crohn disease (CD).ObservationA 53-year-old woman presented with intermittent vulvar and anoperineal lesions since adolescence, seeping and painful during sexual intercourse. We observed an infiltrative and asymmetric oedema of labia majora, perianal oedematous vegetative pseudo-marisca, and groin fold and perianal linear "knife-like" ulcerations. Pathological analysis revealed noncaseating giant cell granulomas. The diagnosis of CD was made. Investigations did not show any intestinal involvement. Anti-TNFα therapy with adalimumab was dramatically efficient.ConclusionAnogenital granulomatosis often precedes intestinal lesions but may also be isolated as in our case. Although treatment is difficult, anti-TNFα seem promising tools.Copyright © 2019 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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