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Review Case Reports
[Fatal intracerebral hemorrhage in a patient with chronic neutrophilic leukemia: About one case and literature review].
- L Talon, B de Renzis, M Fiore, L Sanhes, A-F Sapin, M Berger, T Sinègre, and A Lebreton.
- Service d'hématologie biologique, Hôpital Estaing, Centre hospitalier universitaire de Clermont-Ferrand, place Lucie et Raymond Aubrac, 63003 Clermont-Ferrand, France. Electronic address: ltalon@chu-clermontferrand.fr.
- Rev Med Interne. 2020 Aug 1; 41 (8): 552-558.
IntroductionChronic neutrophilic leukemia (CNL) is a rare myeloproliferative syndrome characterized by a significant increase in mature neutrophils. One of the most serious complications is the occurrence of bleeding events, which may sometimes lead to death.Case ReportA 75-year-old patient presented with CNL, complicated by a severe bleeding phenotype. Biological investigations revealed platelet function defect and increase in neutrophil elastase. The follow-up was marked by an intracranial hemorrhage leading to the patient's death 7 months after diagnosis.ConclusionThis bleeding phenotype has been reported several times in patients with CNL. However, the pathophysiological mechanisms that cause bleeding are not yet fully understood.Copyright © 2020. Published by Elsevier Masson SAS.
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