• Tatjana Gazibara, Lau Caspar Thygesen, Maria Holst Algren, and Janne Schurmann Tolstrup.
• National Institute of Public Health, University of Southern Denmark, Copenhagen K, Denmark.
• J Gen Intern Med. 2020 Sep 1; 35 (9): 2647-2654.

BackgroundPrevious studies have not explored the effect of HPV vaccination on health status at a longer time interval. Similarly, self-reported physical and mental health in recipients of the HPV vaccine has not been studied.ObjectiveTo evaluate whether HPV vaccination was associated with physical and mental health complaints among girls in secondary education institutions.DesignProspective cohort study.ParticipantsThis study used data from girls aged 15-20 years who participated in the Danish National Youth Study (DNYS) 2014. Data on HPV vaccination was retrieved from the Danish Vaccination Register.Main MeasuresParticipants were asked whether they had experienced headaches, stomachache, neck pain, menstrual cramps, sore throat, sadness, irritation, nervousness and sleep problems in the past 6 months.Key ResultsOf 41,333 girls, 39,145 (94.7%) received at least one dose of HPV vaccine. The most prevalent health complaint among the vaccinated and not vaccinated females was "been irritable" (88.2% and 88.4%, respectively). The lowest proportion of health complaints was stomachache (49.6% in vaccinated and in 50.4% in unvaccinated girls). Regression model, adjusted for socio-demographic characteristics and health behavior, showed that HPV vaccination was associated with a lower likelihood of reporting sore throat (odd ratio [OR] 0.86, 95% confidence interval [CI] 0.78-0.95) and being sad (OR 0.86, 95%CI 0.76-0.97). Similar results were observed when HPV vaccination status was analyzed according to the number of doses received.ConclusionWe conclude that HPV vaccination was not associated with physical and mental health complaints among girls in secondary education institutions in Denmark after a median of 5.3 years since HPV vaccination.

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