• J. Korean Med. Sci. · Feb 2020

    Case Reports

    Virus Isolation from the First Patient with SARS-CoV-2 in Korea.

    • Wan Beom Park, Nak Jung Kwon, Su Jin Choi, Chang Kyung Kang, Pyoeng Gyun Choe, Jin Yong Kim, Jiyoung Yun, Gir Won Lee, Moon Woo Seong, Nam Joong Kim, Jeong Sun Seo, and Myoung Don Oh.
    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
    • J. Korean Med. Sci. 2020 Feb 24; 35 (7): e84.

    AbstractNovel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage to China in 25 countries until now. We isolated SARS-CoV-2 from the oropharyngeal sample obtained from the patient with the first laboratory-confirmed SARS-CoV-2 infection in Korea. Cytopathic effects of SARS-CoV-2 in the Vero cell cultures were confluent 3 days after the first blind passage of the sample. Coronavirus was confirmed with spherical particle having a fringe reminiscent of crown on transmission electron microscopy. Phylogenetic analyses of whole genome sequences showed that it clustered with other SARS-CoV-2 reported from Wuhan.© 2020 The Korean Academy of Medical Sciences.

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