• Med Princ Pract · Jan 2020

    Evaluation of Serum Glucagon-Like Peptide 1 and Vitamin D Levels in Elderly Patients with Bone Fractures.

    • Özhan Pazarci, Halef Okan Dogan, Seyran Kilinc, and Yalkin Çamurcu.
    • Department of Orthopedics and Traumatology, Cumhuriyet University School of Medicine, Sivas, Turkey, dr.pazarci@gmail.com.
    • Med Princ Pract. 2020 Jan 1; 29 (3): 219-224.

    ObjectivesTo evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures.Materials And MethodsThis study included 56 patients and 31 control subjects. The patients included were those aged ≥65 years who were admitted to our hospital with a diagnosis of bone fracture. The control group comprised age-matched, healthy individuals. Levels of serum vitamin D and GLP-1 were measured and compared between the 2 groups.ResultsSignificant differences were noted between the groups in terms of serum levels of vitamin D (p < 0.001) and serum levels of GLP-1 (p < 0.001). A positive correlation was observed between serum levels of vitamin D and GLP-1.ConclusionSerum levels of GLP-1 were found to be significantly lower in elderly patients with bone fracture compared to healthy adults. In addition, a significant correlation was found between decreased vitamin D and GLP-1 levels. These results may therefore demonstrate the protective effects of GLP-1 on bone structure and metabolism, similar to those of vitamin D.© 2019 The Author(s) Published by S. Karger AG, Basel.

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