• Cengiz Burak, Muhammed Süleymanoğlu, Mahmut Yesin, Murat Cap, İbrahim Yıldız, İbrahim Rencüzoğulları, Metin Çağdaş, Yavuz Karabağ, Şerif Hamideyin, Doğan İliş, and Erkan Baysal.
• Department of Cardiology, Kafkas University Medical Faculty, Kars, Turkey, cengizburaktyih@yahoo.com.tr.
• Med Princ Pract. 2020 Jan 1; 29 (6): 572-579.

ObjectiveAcute kidney injury (AKI), which is prevalent in ST-segment elevated myocardial infarction (STEMI) patients who have undergone primary percutaneous coronary intervention (PCI), is associated with poor cardiovascular outcomes. As high pulse pressure (PP) is associated with adverse cardiovascular events, the present study's aim was to evaluate the relationship between fractional PP (PPf) and AKI in patients with STEMI who underwent primary PCI.Subjects And MethodsAll laboratory findings as well as echocardiographic and angiographic data of 1,170 consecutive STEMI patients were retrospectively screened. PPf was calculated from the pressures invasively measured after sheath insertion and before performing coronary angiography.ResultsFrom 1,170 eligible STEMI patients (mean age 56 years, 18.2% female), AKI developed in 143 (12.2%) patients. The PPf and pulsatility index were significantly higher in patients with AKI than those without (0.53 ± 0.10 vs. 0.61 ± 0.10, p < 0.001, and 0.80 ± 0.03 vs. 0.82 ± 0.03, p < 0.001, respectively). PPf was also found to be associated with AKI in univariable (OR 2.183, 95% CI 1.823-2.614, p< 0.001) and multivariable (OR 1.874, 95% CI 1.513-2.322, p < 0.001) analysis. In-hospital mortality was higher in patients with AKI than those without.ConclusionInvasively measured PPf, which can be easily measured and has no additional cost in STEMI patients undergoing coronary intervention, is an independent predictor of AKI. In addition, PPf is superior to other blood pressure values and derivatives in AKI prediction.© 2020 The Author(s) Published by S. Karger AG, Basel.

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