• Elif Şenocak Taşçı and Türkay Akbaş.
• Department of Internal Medicine, Acıbadem Mehmet Ali Aydınlar University School of Medicine, Istanbul, Turkey, esenocak@gmail.com.
• Med Princ Pract. 2020 Jan 1; 29 (6): 551-557.

ObjectiveHelicobacter pyloriis responsible for a wide spectrum of diseases. Due to ease of use and access, the standard triple therapy is being used as first-line eradication in many areas. Intestinal metaplasia (IM) is a precancerous lesion that requires eradication therapy. Our aim is to investigate the effect of IM on the standard triple therapy success in H. pylori-positive patients.Subjects And MethodsThe patients who were referred to Düzce University Hospital and Avrasya Hospital Gastroenterohepatology clinic between January 2014 and December 2016 and diagnosed with H. pylori-positive gastritis and underwent first-line eradication were evaluated retrospectively. Biopsy specimens were evaluated according to the updated Sydney system. All patients diagnosed with H. pylori started treatment with pantoprazole 40 mg b.i.d., amoxicillin 1 g b.i.d. and clarithromycin 500 mg b.i.d. for 14 days.ResultsThe mean age of 181 patients included in the study was 55.5 ± 7.8. The success rate of H. pylori eradication was found to be low in severe chronic inflammation (p = 0.001). The success rate was found to be high among patients with no neutrophil activity (p = 0.009). As the intensity of IM increased, density of H. pylori was found to be decreased (p = 0.019). There was no correlation between glandular atrophy, IM, and H. pylori eradication success rate (p = 0.390 and p = 0.812).ConclusionThe severity of chronic inflammation is the most effective Sydney criteria for success of eradication, while the presence on IM does not have any effect.© 2020 The Author(s) Published by S. Karger AG, Basel.

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