• Behzad Babapour, Hossein Doustkami, Leli Avesta, Alireza Moradi, Saeideh Saadat, Kiavash Piralaei, and Mohammad Reza Aslani.
• Department of Cardiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
• Med Princ Pract. 2021 Jan 1; 30 (1): 52-61.

ObjectiveAdipolin/C1q/TNF-related protein-12 is a family of CTRPs highly expressed in adipose tissue with glucose-lowering and anti-inflammatory effects. Various risk factors have been suggested in the incidence of cardiovascular diseases, such as a decrease in anti-inflammatory or an increase in inflammatory factors. The purpose of the present study was to investigate the correlation of adipolin with anthropometric, angiographic, echocardiographic, and biochemical parameters.Subject And MethodsA total of 90 patients who were candidates for angiography were included in the study and divided into 3 groups: 30 patients with acute myocardial infarction (AMI), 30 patients with stable angina pectoris (SAP), and 30 subjects as a control group with a history of chest pain but normal angiography. Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects.ResultsSerum adipolin levels were significantly decreased in patients with AMI compared with the SAP and control groups (p < 0.001 for both). In addition, there was a negative association between serum levels of adipolin and epicardial fat thickness (EFT) and Gensini score in CAD patients. The results of multivariate linear regression analysis revealed that EFT values were independently associated with serum adipolin levels.ConclusionThe current study showed an independent association of adipolin with EFT for the first time in patients with AMI. Decreased adipolin levels in patients with AMI may be involved in the process of atherosclerosis, which requires further study.© 2020 The Author(s) Published by S. Karger AG, Basel.

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