• Eur. J. Intern. Med. · Apr 2020

    Review

    Treat-to-target in systemic lupus erythematosus: Where are we?

    • Roberto Ríos-Garcés, Gerard Espinosa, Ronald van Vollenhoven, and Ricard Cervera.
    • Department of Autoimmune Diseases, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.
    • Eur. J. Intern. Med. 2020 Apr 1; 74: 29-34.

    AbstractSystemic lupus erythematosus (SLE) is the most paradigmatic disorder within systemic autoimmune diseases. The concept and principles of treat-to-target (T2T) in SLE were established half a decade ago and, since then, remarkable advances have been made. An international consensus was organized in order to define and unify the term remission, although plurality, with subtle nuances still exists and has not been overcome. Also, lupus low disease activity state (LLDAS) was coined as an alternative and, perhaps, more realistic target. Both of them have proven to be meaningful in terms of improving several outcomes, and have opened the path for future research in clinical trials. This review arises from the need to summarize the current state of some of the recommendations of the T2T task force.Copyright © 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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