• Wiktoria Leśniak, Laura Morbidoni, Dror Dicker, Ignacio Marín-León, and EFIM.
• 2nd Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland.
• Eur. J. Intern. Med. 2020 Jul 1; 77: 1-5.

AbstractThe rising number of clinical guidelines poses a new challenge to the internists. The main problems are: 1) available documents suffer from heterogeneous methodological quality, and 2) most of clinical guidelines target an 'ideal' patient affected by a single condition, while in real practice internists must face with comorbid patients typically undergoing a polypharmacy. To help address this challenge, EFIM Clinical Practice Working Group started a project aimed to answer a series of relevant clinical questions, by selecting the best available guidance containing recommendations applicable to complex patients under polypharmacy. The project started with the creation of a research protocol containing details about all the steps needed to write the Clinical Practice Guideline Summary. In particular, this methodological document specifies the rules: 1) to select topics and clinical questions; 2) to build up a panel of experts, carefully managing eventual conflict of interests; 3) to critically appraise clinical guidelines (using a validated tool as AGREE II), selecting the most valid and applicable to the common clinical practice (using ADAPTE; 4) to address and solve potential disagreements among the selected documents.Copyright © 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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