• Internal medicine · Jan 2020

    Case Reports

    The Administration of Tenofovir Disoproxil Fumarate for Pregnant Japanese Women with Chronic Hepatitis B.

    • Maito Suoh, Akihiro Tamori, Yuga Amano-Teranishi, Takashi Nakai, Masaru Enomoto, Yasuko Kawasaki, Kiyohide Kioka, and Norifumi Kawada.
    • Department of Hepatology, Osaka City General Hospital, Japan.
    • Intern. Med. 2020 Jan 1; 59 (2): 205210205-210.

    AbstractThe appropriate management of hepatitis B virus (HBV) infection during pregnancy has not been established in Japan. We herein report five HBV-infected pregnant Japanese women who received tenofovir disoproxil fumarate (TDF). Two of them had been born after the introduction of nationwide immunoprophylaxis and were vertically infected with HBV, highlighting the need to address mother-to-child transmission further. In both entecavir-experienced and nucleoside/nucleotide analog-naïve mothers, TDF suppressed HBV replication without serious adverse events. All five children were free from congenital disorders, growth impairment, and HBV infection. TDF showed safety and efficacy for pregnant woman with chronic hepatitis B and might have helped prevent mother-to-child transmission.

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