• Kazuto Katsuse, Genki Shimizu, Naoko Saito Sato, Keiko Hatano, Shintaro Yagi, Toshikazu Kimura, Koreaki Irie, Shunsuke Ichi, Toshiyuki Takahashi, and Hideji Hashida.
• Department of Neurology, Japanese Red Cross Medical Center, Japan.
• Intern. Med. 2020 Jun 1; 59 (11): 1445-1449.

AbstractAnti-myelin oligodendrocyte glycoprotein (MOG) antibodies have been associated with steroid-responsive cortical encephalitis and comorbid generalized epilepsy. A 44-year-old woman developed repeated epilepsia partialis continua (EPC) without generalized seizures and was anti-MOG antibody-positive. Radiological abnormalities were detected in the bilateral medial frontoparietal cortices, but there were no cerebrospinal fluid abnormalities. She achieved remission with anti-epileptic drugs alone. However, encephalitis recurred four months later when pleocytosis appeared, and steroid therapy was effective. Altogether, EPC without typical cerebrospinal fluid features can be an early sign of anti-MOG antibody-positive encephalitis. Thus, patients with EPC of unknown etiology need to be screened for anti-MOG antibodies.

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