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Case Reports
Failure of Liposomal-amphotericin B Treatment for New World Cutaneous Leishmaniasis due to Leishmania braziliensis.
- Atsushi Kosaka, Naoya Sakamoto, Mayu Hikone, Kazuo Imai, Masayuki Ota, Takuya Washino, Takuya Maeda, and Sentarou Iwabuchi.
- Department of Infectious Diseases, Tokyo Metropolitan Bokutoh Hospital, Japan.
- Intern. Med. 2020 Jan 1; 59 (9): 1227-1230.
AbstractLiposomal-amphotericin B (L-AmB) is used for cutaneous leishmaniasis (CL); however, its treatment failure has not yet been described in detail. A 58-year-old man returned from the Republic of Venezuela with a cutaneous ulcer on his left lower leg. The causative pathogen was Leishmania braziliensis. We started L-AmB 3 mg/kg/day for 6 days; however, the ulcer did not resolve. The patient was successfully retreated with a higher dose L-AmB 4 mg/kg/day 9 times (total, 36 mg/kg). If L-AmB fails to treat CL and other therapeutics cannot be used, increasing the L-AmB dose is a viable option.
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