• Medicina · Apr 2020

    Review Case Reports

    Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review.

    • Carmen Adella Sirbu, Elena Dantes, Cristina Florentina Plesa, Any Docu Axelerad, and Minerva Claudia Ghinescu.
    • Neurology Department, Titu Maiorescu University, 040441 Bucharest, Romania.
    • Medicina (Kaunas). 2020 Apr 24; 56 (4).

    AbstractIn this paper, we reported on four cases of severe pulmonary active tuberculosis in patients with multiple sclerosis (MS) undergoing interferon beta-1b (IFNβ-1b) therapy. Disease-modifying therapies (DMTs) in MS may increase the risk of developing active tuberculosis (TB) due to their impact on cellular immunity. Screening for latent infection with Mycobacterium tuberculosis (LTBI) should be performed, not only for the newer DMTs (alemtuzumab, ocrelizumab) but also for IFNβ-1b, alongside better supervision of these patients.

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