• Pietro Brunetti, Simona Pichini, Roberta Pacifici, Francesco Paolo Busardò, and Alessandro Del Rio.
• Department of Excellence of Biomedical Sciences and Public Health, "Politecnica delle Marche" University of Ancona, Via Tronto 71, 60126 Ancona, Italy.
• Medicina (Kaunas). 2020 May 15; 56 (5).

AbstractCannabis has been used for centuries for therapeutic purposes. In the last century, the plant was demonized due to its high abuse liability and supposedly insufficient health benefits. However, recent decriminalization policies and new scientific evidence have increased the interest in cannabis therapeutic potential of cannabis and paved the way for the release of marketing authorizations for cannabis-based products. Although several synthetic and standardized products are currently available on the market, patients' preferences lean towards herbal preparations, because they are easy to handle and self-administer. A literature search was conducted on multidisciplinary research databases and international agencies or institutional websites. Despite the growing popularity of medical cannabis, little data is available on the chemical composition and preparation methods of medical cannabis extracts. The authors hereby report the most common cannabis preparations, presenting their medical indications, routes of administration and recommended dosages. A practical and helpful guide for prescribing doctors is provided, including suggested posology, titration strategies and cannabinoid amounts in herbal preparations obtained from different sources of medical cannabis.

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