• Fatemeh Shirani, Ali Teimoori, Andrew J McAinch, Mohammad Rashno, Seyed Mahmoud Latifi, and Majid Karandish.
• Department of Nutrition, School of Allied Medical Sciences, and Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
• J. Investig. Med. 2020 Jun 1; 68 (5): 980-984.

AbstractHuman adenovirus 36 (Ad-36) causes obesity with increased adiposity, in contrast, Ad-36 infection reduces glucose and lipid metabolism; the results, however, are not consistent. In the current study, the effects of Ad-36 infection on glucose and lipid profile and inflammatory markers in Wistar rats were investigated. Sixty male Wistar rats were randomly divided into infected and control groups. Ad-36 virus suspension was injected in the experimental group rats. Blood samples were collected in the beginning and after 12 weeks in both groups. After 12 weeks, a significant improvement was observed in fasting blood glucose, fasting serum insulin, insulin sensitivity, serum triglycerides and total cholesterol in the infected group compared with the non-infected groups. There were no significant differences in inflammatory biomarkers including tumor necrosis factor-α, interleukin 6 and monocyte chemoattractant protein-1 levels between infected and control groups. This study showed that Ad-36 had favorable effects on glycemic and lipid control in infected rats, but inflammatory biomarker levels were similar for 2 groups. Ad-36 infections could potentially be a new way to develop novel antidiabetic and antihyperlipidemic therapeutic agents.© American Federation for Medical Research 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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