• J Eval Clin Pract · Dec 2019

    Evidential Proximity, Independence, and the evaluation of carcinogenicity.

    • Jon Williamson.
    • Department of Philosophy, University of Kent, Canterbury, UK.
    • J Eval Clin Pract. 2019 Dec 1; 25 (6): 955-961.

    AbstractThis paper analyses the methods of the International Agency for Research on Cancer (IARC) for evaluating the carcinogenicity of various agents. I identify two fundamental evidential principles that underpin these methods, which I call Evidential Proximity and Independence. I then show, by considering the 2018 evaluation of the carcinogenicity of styrene and styrene-7,8-oxide, that these principles have been implemented in a way that can lead to inconsistency. I suggest a way to resolve this problem: admit a general exception to Independence and treat the implementation of Evidential Proximity more flexibly where this exception applies. I show that this suggestion is compatible with the general principles laid down in the 2019 version of IARC's methods guide, its Preamble to the Monographs.© 2019 The Authors Journal of Evaluation in Clinical Practice Published by John Wiley & Sons Ltd.

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