• Linsha Dong, Zhuoma Dongzhi, Yonglong Jin, Youn-Chul Kim, Dong-Sung Lee, Shan Huang, Pharkphoom Panichayupakaranant, and Bin Li.
• Department of Pharmacy, Qingdao University of Science and Technology, Qingdao, China.
• Am. J. Chin. Med. 2020 Jan 1; 48 (2): 445-462.

AbstractAs a long-established medicinal and edible homologous plant, Taraxacum officinale Wigg. is widely distributed in Asia, Europe, and other parts of the world. T. officinale is reported to exert a variety of biological and pharmacological activities, including anticancer, hepatoprotective, and anti-obesity effects. In this study, we evaluated the anti-inflammatory effects of ethanol extracts of T. officinale (A-TOW) by examining the suppression of proinflammatory mediators in LPS-stimulated BV2 and mouse hippocampus. Furthermore, A-TOW also inhibited the nuclear translocation of nuclear factor κ B p65 caused by stimulation with LPS. In addition, A-TOW regulates heme oxygenase (HO)-1 expression through the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in BV2 cells. The effects of A-TOW on the over-expression of proinflammatory mediators were partially reversed by transfection of the cells with HO-1 siRNA. These findings suggest that the potent anti-inflammatory activity of T. officinale, possibly through the regulation of Nrf2/HO-1 and NF- κ B signaling pathway.

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