Gastrointestinal endoscopy
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Gastrointest. Endosc. · Jan 1997
Randomized Controlled Trial Clinical TrialSedation and analgesia for colonoscopy: patient tolerance, pain, and cardiorespiratory parameters.
Colonoscopy is generally performed with the patient sedated and receiving analgesics. However, the benefit of the most often used combination of intravenous midazolam and pethidine on patient tolerance and pain and its cardiorespiratory risk have not been fully defined. ⋯ In this study, the combination of low-dose midazolam and pethidine does not improve patient tolerance and lessen pain during colonoscopy as compared with either drug given alone. When applying low-dose midazolam, oxygen desaturation and hypotension do not occur more often after combined use of both drugs. For the individual patient, sedation and analgesia should be based on the endoscopist's clinical judgement.
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Gastrointest. Endosc. · Jan 1997
Randomized Controlled Trial Clinical TrialNitrous oxide inhalation as sedation for flexible sigmoidoscopy.
Flexible sigmoidoscopy is usually performed without sedation in screening programs for colorectal cancer. Most patients report some degree of discomfort or pain during the procedure. The aim of this study was to evaluate self-administered nitrous oxide as a method to reduce patient discomfort, thereby improving the procedure and conceivably increasing patient compliance and motivation. ⋯ The addition of "on demand" nitrous oxide did not improve sigmoidoscopy performance or diminish pain and discomfort. However, further studies using improved administration techniques and larger study groups are justified in the search for ways to increase compliance with and motivation for colorectal cancer screening.