Gastrointestinal endoscopy
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Gastrointest. Endosc. · Jun 1999
Randomized Controlled Trial Comparative Study Clinical TrialEfficacy and safety of intravenous propofol sedation during routine ERCP: a prospective, controlled study.
Adequate patient sedation is mandatory for diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). The short-acting anesthetic propofol offers certain potential advantages for endoscopic procedures, but controlled studies proving its superiority over benzodiazepines for ERCP are lacking. ⋯ Intravenous sedation with propofol for ERCP is (1) more effective than sedation with midazolam, (2) safe under adequate patient monitoring, and (3) associated with a faster postprocedure recovery.
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Gastrointest. Endosc. · Jun 1999
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of midazolam and diazepam for conscious sedation during colonoscopy in a prospective double-blind study.
Midazolam and diazepam are commonly used for conscious sedation, but their comparative respiratory depressive effects have not been accurately studied. We used a novel real-time, on-line, computerized data acquisition system to compare the two agents in a randomized double-blind study. ⋯ Midazolam was 3.4 times more potent than diazepam. The duration of oxygen desaturation emphasizes the importance of monitoring SpO2 until ventilation and oxygenation have recovered. Although the degree of hypoxemia was comparable, midazolam led to higher end-tidal carbon dioxide tensions.