Gastrointestinal endoscopy
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Gastrointest. Endosc. · Jan 2006
Randomized Controlled TrialDiphenhydramine as an adjunct to sedation for colonoscopy: a double-blind randomized, placebo-controlled study.
Intravenous benzodiazepines in combination with opiates are used to achieve moderate sedation for colonoscopy. Although effective, these agents have potential adverse effects, such as respiratory depression and hypotension. Diphenhydramine hydrochloride possesses central nervous system depressant effects that theoretically could provide a synergistic effect for sedating patients. ⋯ Intravenous diphenhydramine given before initiation of standard sedation offers a significant benefit to conscious sedation for patients undergoing colonoscopy.