Biomechanics and modeling in mechanobiology
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Biomech Model Mechanobiol · Oct 2019
Paediatric brain tissue properties measured with magnetic resonance elastography.
The aim of this study is to characterise the stiffness of white and grey matter in paediatric subjects using magnetic resonance elastography (MRE) and to determine whether these properties change throughout normal development. MRE was performed using a clinical 3T MRI scanner at three frequencies (30, 40 and 60 Hz) on 36 healthy paediatric subjects aged between 7 and 18 years (19 F) and 11 adults aged 23-44 years (6 F). Anatomical and diffusion tensor imaging was also collected. ⋯ Adult G*, FA, MD and volume values were within range of others reported in the literature. Paediatric white and grey matter stiffness values are similar to those of adults. We conclude that clinically, adult values can be used as a baseline measure in paediatric brain MRE.