Clinical physiology and functional imaging
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Clin Physiol Funct Imaging · Mar 2006
Multiple pressure-volume loops recorded with sinusoidal low flow in a porcine acute respiratory distress syndrome model.
To develop a method for automatic recording of multiple dynamic elastic pressure-volume (P(el)/V) loops. To analyse the relationship between multiple dynamic P(el)/V loops and static P(el)/V loops in a porcine model of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). To test the hypothesis that increasing lung collapse and re-expansion with decreasing positive end expiratory pressure (PEEP) can be characterized by hysteresis of the P(el)/V loops. MATERIAL AND INTERVENTIONS: In eight anaesthetized and paralysed pigs, ALI/ARDS was induced by inhalation of dioctyl sodium sulfosuccinate and large tidal volume ventilation. ⋯ Automated multiple P(el)/V loop determination is feasible and provides comprehensive information on lung derecruitment and recruitment. It requires determination of volume dependence of expiratory resistance. An expiratory curve serves as a reference to inspiratory curves and provides information about hysteresis.