Lancet neurology
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Amyotrophic lateral sclerosis (ALS) is considered to be caused by both genetic and environmental factors. The causal cascade is, however, not known. We aimed to assess lifestyle during the presymptomatic phase of ALS, stratified by C9orf72 mutation, and examine evidence supporting causality of lifestyle factors. ⋯ Netherlands ALS Foundation.
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Meta Analysis
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.
The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. ⋯ British Heart Foundation.