Respiratory physiology & neurobiology
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Respir Physiol Neurobiol · Mar 2011
Clinical TrialEffects of venous compression of the legs on overnight rostral fluid shift and obstructive sleep apnea.
The amount of fluid displaced overnight from the legs into the neck as a consequence of lying recumbent correlates with the number of apneas and hypopneas per hour of sleep (AHI). Sedentary living promotes dependent fluid accumulation in the legs that can be counteracted by venous compression of the legs (compression stockings). ⋯ The median AHI decreased from 30.9 (interquartile range 19.6-60.4) to 23.4 (12.9-31.8) (P=0.016) in association with a median 40% reduction in the change in leg fluid volume (P=0.016) and a median 42% reduction in the increase in neck circumference (P=0.016). These results provide proof-of-principle that overnight fluid displacement into the neck plays a causative role in OSA.