Respiratory physiology & neurobiology
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Respir Physiol Neurobiol · May 2014
Comparative Study Clinical TrialPhysiological comparison of breathing patterns with neurally adjusted ventilatory assist (NAVA) and pressure-support ventilation to improve NAVA settings.
Neurally adjusted ventilator assist (NAVA) assists spontaneous breathing in proportion to diaphragmatic electrical activity (EAdi). Here, we evaluate the effects of various levels of NAVA and PSV on the breathing pattern and, thereby, on [Formula: see text] homeostasis in 10 healthy volunteers. For each ventilation mode, four levels of support (delivered pressure 0 i.e. baseline, 5, 8, and 10cmH2O) were tested in random order. ⋯ Diaphragmatic activity can decrease during NAVA without any change in VT and [Formula: see text]. This suggests that NAVA adjustment cannot be based solely on VT and [Formula: see text] criteria. Registered by Frédéric Lofaso and Nicolas Terzi on ClinicalTrials.gov, #NCT01614873.