The Annals of otology, rhinology, and laryngology
-
Ann. Otol. Rhinol. Laryngol. · Oct 2016
Randomized Controlled TrialCelecoxib Versus Placebo in Tonsillectomy: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial.
Celecoxib is a cyclooxygenase-2-specific inhibitor indicated to treat acute pain and pain secondary to osteoarthritis and rheumatoid arthritis. Surgical models of acute pain have demonstrated superior pain relief to placebo. The objective of this study was to test the safety and efficacy of celecoxib for pain relief after tonsillectomy compared to placebo. ⋯ In this small cohort, celecoxib reduced postoperative narcotic and acetaminophen requirements compared to placebo without complications.
-
Ann. Otol. Rhinol. Laryngol. · May 2016
Randomized Controlled TrialOxymetazoline Applied Topically to the Nasal Mucosa Decreases Trans-Mucosal Nitrous Oxide Exchange for the Middle Ear.
Determine if the middle ear (ME) trans-mucosal nitrous oxide (N2O) gas exchange rate can be pharmacologically modulated by the nasal application of a vasoconstrictor. ⋯ The exchange rate across the ME mucosa of inert gases can be decreased by topical treatment of the nasal mucosa with oxymetazoline.