Ugeskrift for laeger
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Ugeskrift for laeger · Nov 1999
Case Reports[Respiratory depression following medication change from tramadol to morphine].
Respiratory depression following change of medication from tramadol to morphine is described in two patients. Tramadol is metabolized by cytochromoxidase CYP2D6 to O-desmethyl-tramadol with opioid agonist activity. ⋯ When tailoring analgesia, the lack of response to tramadol may be interpreted as a need for opioid dose increase. In such cases, excessive opioid doses may be prescribed resulting in opioid side effects.
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Ugeskrift for laeger · Nov 1999
Comparative Study[Trends concerning medical articles 1989-1998. A study of Danish articles compared to other members of the European Union].
The paper analyses the development of the total number of journal articles indexed in the Medline database published by authors affiliated to Denmark 1989-1998 in medicine compared to the development in the European Union during the same period. The publication analysis is then compared to the citation impact of articles published in the central journals indexed in Science Citation Index (ISI) 1987-1996 through use of the National Science Indicators (NIS, ISI) database. ⋯ By population, Denmark ranked third in total number of articles in 1998. In conclusion, Denmark is very active in medical research but neither the quantity nor the quality of Danish medical research has increased at the same rate as the EU average.