Ugeskrift for laeger
-
Ugeskrift for laeger · May 2002
Review[STI571 (Glivec)--a new drug for the treatment of chronic myeloid leukemia].
Chronic myeloid leukaemia (CML) is characterised by the occurrence of the Philadelphia (Ph) chromosome (9/22 translocation) and the formation of a fusion protein--the BCR-ABL transcript with constitutive activation of the BCR-ABL tyrosine kinase and consequent changes in the intracellular signal transduction, which is responsible for the deregulated myeloid cell proliferation. STI571 (signal transduction inhibition number 571) is a potent and selective inhibitor of the BCR-ABL tyrosine kinase. ⋯ Side effects are primarily nausea, vomiting, various rashes, oedema, most often in the periorbital region, and musculoskeletal symptoms, including muscle cramps. Perspectives for treatment with STI571 are described, as are combinations with alpha-interferon and other cytostatics with a synergistic profile.
-
Ugeskrift for laeger · May 2002
[The association between physical workload and low back pain clouded by the "healthy worker" effect].
Both physical and psychosocial workplace factors are considered risk factors for low back pain (LBP). However, today, no consensus has been reached regarding the exact role of these factors in the genesis of LBP. ⋯ Having a sedentary job might have a protective or neutral effect in relation to LBP, whereas having a heavy physical job constitutes a significant risk factor. Because og migration between exposure groups (the "healthy worker" effect), longitudinal studies are necessary for investigating the associations between physical workload and LBP.
-
The aim of the study was to gain experience with continuous electronic registration of data regarding surgical postoperative wound infection after heart surgery. ⋯ The study showed that risk stratification of data in relation to postoperative wound infection after heart surgery can be registered continuously in a central database. Registration of all postoperative wound infections requires several resources and may be incomplete. However, the high quality of registration of deep wound infection and risk stratification indicates that registration of deep wound infection could be an indicator of clinical quality.