Ugeskrift for laeger
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Ugeskrift for laeger · Aug 2002
[Thrombolysis in apoplexy. How big is the target group and how many benefit?].
At present it is possible to dissolve cerebral blood clots with thrombolysis. This is a standard treatment in the USA and Canada for early onset ischaemic strokes within three hours of the stroke. Acceptance of thrombolysis is based on a single clinical trial. However, three other clinical trials have cast doubt on the benefit of the treatment and it has not yet been approved in Denmark and other countries. We sought to investigate the possible impact of thrombolysis in an unselected Danish stroke population. ⋯ Our study shows that few stroke patients would benefit from thrombolysis. The result is very well in line with the clinical experiences reported from the USA. Introduction of thrombolysis in Denmark to benefit the few would require extensive reorganisation of stroke care.
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Since 1991, the Danish Junior Doctors' Association has carried out annual investigations among its members in regard to education. In 2001, the questionnaire included a special section about scientific activities. ⋯ The publication rate has declined over the past ten years, which has many reasons. One reason is the increasing number of PhD-degrees and an increase in the impact factor, which means qualitative research improvement. A changed procedure in the postgraduate education is a factor as well. The low recruitment of junior doctors for pregraduate education seems to be a constant problem.
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Ugeskrift for laeger · Aug 2002
Review[Obsessive-compulsive disorders in children. Subtypes of OCD and their relation to infection with group A streptococci].
The present review describes the theory of a spectrum of obsessive-compulsive disorders (OCD). This spectrum includes such disorders as trichotillomania, eating disorders, body dysmorphic disorder, and possibly pervasive developmental disorders. OCD with an onset in childhood is presented as a specific subtype, with more boys affected and frequently co-morbid with tics and Tourette's syndrome. ⋯ This subtype of OCD is, still on a speculative basis, connected to infections with beta-haemolytic streptococci. The obsessive-compulsive symptoms are characterised by a sudden onset, "sawtoothed" course with relapses and remissions, and are associated with neurological abnormalities. There are still no clinical consequences in terms of penicillin treatment of this PANDAS subtype of OCD.