Ugeskrift for laeger
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Few investigations have elucidated the acute inflammatory response after accidental trauma before the patients were anesthetized and treated with analgetics and intravenous fluid. The cellular immunological response seems to be characterized by an initial activation followed by suppression. In major tissue trauma, the granulocytes are the major effector cells. ⋯ The antigen presentation capacity of monocytes and the cytotoxicity of NK-cells are reduced following major trauma. High concentrations of proinflammatory and antiinflammatory cytokines can be measured locally in the injured tissue. In uncomplicated cases, elevated cytokine concentrations are measured in the blood for a few days, whereas a sustained high cytokine production seems to correlate with organ dysfunction and mortality.
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Ugeskrift for laeger · Feb 2003
Comparative Study[Measuring of preoperative anxiety by three self-reporting scales: State Trait Anxiety Inventory, Symptoms CheckList 92 and visual analogue scale].
Preoperative anxiety is a common phenomenon. It is therefore necessary to investigate whether quantitative self-reporting anxiety scales can be helpful in the anaesthetic clinic and research. The aim of this study was to compare the state trait anxiety inventory (STAI), symptoms checklist 92 (SCL 92), the subscales anxiety and phobic anxiety, and a visual analogue scale for anxiety (VAS). ⋯ In this study the STAI scale, SCL 92 anxiety, and VAS measure all essential features of the phenomenon. SCL 92 anxiety is nevertheless considered to be the most appropriate rating scale, because it has been validated in a Danish population.