Ugeskrift for laeger
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Ugeskrift for laeger · Jul 2003
Review[Recurrence after surgery of varices in the region of the long saphenous vein].
The article documents that among patients with saphenofemoral reflux inadequate surgery on the saphenofemoral junction was the cause of recurrence in 40% and 43% respectively of patients treated at hospitals and in out-clinics, but in only 14% when operation was performed by a specialized vascular surgeon. The causes of recurrence are described in the literature as follows: inadequate ligation, recanalisation, neovascularisation, non-saphenofemoral reflux, long saphenous vein duplication, incompetent perforator veins and inadequate stripping of the long saphenous vein. ⋯ The surgeon may reduce recurrence rates by combining stripping of the long saphenous vein to the knee including duplications with thorough ligation of the saphenofemoral junction and ligation of adjacent side-branches. Stab avulsions are obligatory.
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Ugeskrift for laeger · Jul 2003
[Blockade of endothelin receptor with bosentan--a new principle of treatment in pulmonary arterial hypertension].
Blockade of endothelin receptors is a new drug principle for the treatment of pulmonary arterial hypertension. Bosentan is a competitive blocker of endothelin receptors administered by the oral route. In clinical trials it has been shown to increase the functional capacity of patients with pulmonary arterial hypertension. This article describes the background, results of clinical trials, and practical guidelines for the use of bosentan in pulmonary arterial hypertension.