Ugeskrift for laeger
-
Ugeskrift for laeger · Mar 2016
Case Reports[Perimortem caesarean section and timely decision making].
Perimortem caesarean section can be decisive for the outcome of a cardiac arrest in pregnancy for both mother and fetus. We describe a case story of the management of cardiac arrest in early labour where perimortem caesarean section proved to be life-saving for both mother and child. ⋯ The mother recovered well with no serious sequelae to the resuscitation. We discuss the importance of timely decision and execution of perimortem caesarean.
-
Zika virus is endemic in several parts of the world. February 1, 2016 Zika virus was declared a public health emergency by the WHO. This declaration is mainly due to a convincing association between Zika virus infection during pregnancy and birth defects, like microcephaly, among some of the newborns. ⋯ The infection in itself is mild and self-limiting. The available diagnostic methods are under development, validation and evaluation. In Denmark, some promising diagnostics are available at Statens Serum Institut.
-
Passive anti-beta-amyloid (Aß) immunotherapy has been shown to clear brain Aß deposits. Results from phase III clinical trials in mild-to-moderate Alzheimer's disease (AD) patients with two monoclonal antibodies bapineuzumab and solanezumab and intravenous immunoglobulin have been disappointing. Subsequent analysis of pooled data from both phase III trials with solanezumab showed a reduction in cognitive decline in patients with mild AD. Solanezumab and new monoclonal antibodies are being tested in patients with prodromal and preclinical AD in search for a disease-modifying treatment.
-
Ugeskrift for laeger · Nov 2015
Review[Clonidine can reduce opioid medication during post-operative pain].
Post-operative pain management can be a challenge, and one of the first choices seems to be opioids. However, opioids have undesirable side effects, and attention may lead to a multimodal analgesia. The use of clonidine is a part of this strategy. ⋯ Overall, there is a good effect of post-operative pain management. Side effects as hypotension and sedation are mentioned but not as a limitation. Many anaesthesiologists do already use clonidine in the management of post-operative pain, but more research about intravenous administration of clonidine is needed.
-
Ugeskrift for laeger · Nov 2015
Case Reports[Post-partum posterior reversible encephalopathy syndrome].
Posterior reversible encephalopathy syndrome (PRES) is a complex clinical condition with vasogenic subcortical oedema caused by hypertension. Oedema is often seen on magnetic resonance imaging. ⋯ In this case report we emphasize the importance of blood pressure control in a post-partum woman, who had a rather complicated pregnancy. The symptoms of PRES were not recognized immediately because of failure to use and acknowledge a blood pressure test.