Ugeskrift for laeger
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A 68-year-old woman was admitted for open heart surgery. She had no history of allergy, but had suffered acute heart failure after having received protamine twice. Possible predisposition to adverse reactions is discussed and ways of reducing adverse reactions to protamine are suggested.
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Ugeskrift for laeger · Aug 2002
[Thrombolysis in apoplexy. How big is the target group and how many benefit?].
At present it is possible to dissolve cerebral blood clots with thrombolysis. This is a standard treatment in the USA and Canada for early onset ischaemic strokes within three hours of the stroke. Acceptance of thrombolysis is based on a single clinical trial. However, three other clinical trials have cast doubt on the benefit of the treatment and it has not yet been approved in Denmark and other countries. We sought to investigate the possible impact of thrombolysis in an unselected Danish stroke population. ⋯ Our study shows that few stroke patients would benefit from thrombolysis. The result is very well in line with the clinical experiences reported from the USA. Introduction of thrombolysis in Denmark to benefit the few would require extensive reorganisation of stroke care.