Ugeskrift for laeger
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Ugeskrift for laeger · Dec 1999
Randomized Controlled Trial Comparative Study Clinical Trial[Complications after spinal analgesia using three different spinal needles: Sprotee, Spinocan and Atraucan].
In this prospective, randomised study 197 patients aged below 40 years received spinal analgesia using one of the following needles: Sprotte G24, Spinocan G27 or Atraucan G26. The incidence of insufficient or failed analgesia and difficulties handling the needles were noted. Patients were interviewed within three weeks after anaesthesia so as to establish the incidence of postoperative complications including post-dural puncture headache (PDPH). ⋯ Furthermore a significantly lower incidence of insufficient analgesia was observed with the Sprotte needle (0% versus 12.1% with the Spinocan and 11.6% with the Atraucan, p < 0.05). In conclusion, the Sprotte needle had the best profile with respect to PDPH and successful analgesia. This confirms the importance of the needle tip design.
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Ugeskrift for laeger · Nov 1999
Case Reports[Respiratory depression following medication change from tramadol to morphine].
Respiratory depression following change of medication from tramadol to morphine is described in two patients. Tramadol is metabolized by cytochromoxidase CYP2D6 to O-desmethyl-tramadol with opioid agonist activity. ⋯ When tailoring analgesia, the lack of response to tramadol may be interpreted as a need for opioid dose increase. In such cases, excessive opioid doses may be prescribed resulting in opioid side effects.
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Ugeskrift for laeger · Nov 1999
Comparative Study[Trends concerning medical articles 1989-1998. A study of Danish articles compared to other members of the European Union].
The paper analyses the development of the total number of journal articles indexed in the Medline database published by authors affiliated to Denmark 1989-1998 in medicine compared to the development in the European Union during the same period. The publication analysis is then compared to the citation impact of articles published in the central journals indexed in Science Citation Index (ISI) 1987-1996 through use of the National Science Indicators (NIS, ISI) database. ⋯ By population, Denmark ranked third in total number of articles in 1998. In conclusion, Denmark is very active in medical research but neither the quantity nor the quality of Danish medical research has increased at the same rate as the EU average.
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Ugeskrift for laeger · Oct 1999
Review Comparative Study[Activated charcoal in the treatment of acute drug poisonings].