African health sciences
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African health sciences · Dec 2013
Knowledge about the research and ethics committee at Makerere University, Kampala.
All research involving human participants should be reviewed by a competent and independent institutional research and ethics committee. Research conducted at Makerere University College of Health Sciences should be subjected to a rigorous review process by the ethics committee in order to protect human participants' interests, rights and welfare. ⋯ Respondents knew the major functions of the committee including protection of the rights and welfare of research participants, protocol review and monitoring of on going research, and the elements of protocol review that are given more attention include ;scientific design and ethical issues. Overall performance of the REC was ranked as average by respondents. The committee should limit delays in approval and effectively handle all functions of the committee.
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African health sciences · Dec 2013
Antihypercholesterolemic activity of ethanolic extract of Buchholzia coriacea in rats.
Hypercholesterolemia is a condition characterised with high level of cholesterol in the blood. ⋯ The results suggest that Buchholzia coriacea seeds contain potent antihypercholesterolemic agent which may find clinical application in ameliorating hypercholesterolemia and its attendant complications.
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African health sciences · Dec 2013
ReviewA review of the management of perforated duodenal ulcers at a tertiary hospital in south western Nigeria.
Gastro-duodenal perforations are common and may complicate peptic ulcer disease. Management is often by surgical closure. ⋯ Late presentation of duodenal ulcer perforation is common with high mortality. Pragmatic surgical intervention with Graham's omentopexy with broad spectrum antibiotics is still commonly practiced.
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African health sciences · Dec 2013
Causes and outcome of hospitalization among HIV-infected adults receiving antiretroviral therapy in Mulago hospital, Uganda.
Cohorts describing cause specific mortality in HIV-infected patients initiating antiretroviral therapy (ART) operate on an outpatient basis. Hospitalized patients represent the spectrum and burden of severe morbidity and mortality in patients on ART. ⋯ Opportunistic infections, malignancy and AZT-associated anemia contributed to most hospitalizations and mortality. It is important to intensify prevention, screening, and treatment for these opportunistic diseases and early ART initiation in HIV-infected patients. Tenofovir-based regimens, unless contraindicated should be scaled up to replace AZT-based regimens as first line ART drugs.