African health sciences
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African health sciences · Jun 2018
Histo-pathological pattern of intracranial tumours in the National Hospital, Abuja.
Intracranial tumours demonstrate characteristic diagnostic histopathological features. Our aims were to look at the histo-pathological pattern of intracranial tumours in our environment including their age and sex distribution. ⋯ The histo-pathological pattern of intracranial tumours in our environment showed that meningioma is the most common intracranial tumour in adults, while glioma and embryonal tumours are the most common intracranial tumours in children.
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African health sciences · Jun 2018
MicroRNA expression profiling in human acute organophosphorus poisoning and functional analysis of dysregulated miRNAs.
Acute organophosphorus(OP) pesticide poisoning is associated with dysfunctions in multiple organs, especially skeletal muscles, the nervous system and the heart. However, little is known about the specific microRNA (miRNA) changes that control the pathophysiological processes of acute OP poisoning damage. We aimed to explore miRNA expression profiles and gain insight into molecular mechanisms of OP toxic effects. ⋯ This study mapped changes in the serum miRNA expression profiles of poisoning patients and predicted functional links between miRNAs and their target genes in the regulation of acute OP poisoning. Our findings are an important resource for further understanding the role of these miRNAs in the regulation of OP-induced injury.
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African health sciences · Jun 2018
Compliance with epidemic-prone diseases surveillance and response guidelines among health officers at surveillance units in South-West Nigeria.
Although compliance with surveillance guidelines is crucial to epidemic diseases control, determinants of use of these guidelines in Nigeria are poorly documented. We assess health workers compliance and factors associated with the surveillance and response guidelines for epidemic-prone diseases in South-West Nigeria. ⋯ In addition to provision of adequate financial and laboratory resources, surveillance activities would benefit from continuous training on surveillance data flow.
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African health sciences · Jun 2018
Impact of weight reduction on selected immune system response among Hepatitis C virus Saudi patients.
Recently, about 2.35% of the world populations are estimated to be chronically infected with hepatitis C virus (HCV). Previous cohort studies indicated that obesity increases risk of hepatic steatosis and fibrosis in non-diabetic patients with chronic hepatitis C infection due to diminished response to anti-viral therapy and as a result obesity is considered as an important factor in the progression of chronic HCV. However, there is a strong association between BMI and the human immune system among HCV patients. ⋯ Weight loss modulates immune system parameters of patients with HCV.
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African health sciences · Jun 2018
Interleukin-6 gene -572G/C polymorphism and prostate cancer risk.
The aim of the present study was to determine whether the interleukin-6 (IL-6) -572G/C polymorphism correlates with prostate cancer. ⋯ Our findings demonstrated that the -572G/C polymorphism of the IL-6 gene may be a risk factor for the development of prostate cancer in Asians.